Sickle Cell Anemia (Subscribe)

Avascular necrosis of the femoral head in sickle-cell disease. Treatment of collapse by the injection of acrylic cement. Hernigou P, Bachir D, Galacteros F. Henri Mondor Hospital, Creteil, France. In ten patients with sickle-cell disease, we used a new technique of cement injection for the treatment of 16 painful hips with a radiographic...

Although sickle cell disease (SCD) is characterized by a marked heterogeneity in clinical and hematologic severity [1,2], bone and joint problems are the most common manifestations. Pain, caused by vaso-occlusive crises (VOC), may occur as often as every week or as rarely as once a year. Many patients also suffer...

Search String "sickle cell" osteonecrosis dactylitis osteomyelitis

The primary goal of the Information Center for Sickle Cell and Thalassemic Disorders is to provide the most accurate and up-to-date information on hemoglobin disorders, particularly sickle cell disease and thalassemia, as well as disordrers of iron metabolism. The information is designed to be useful to health care personnel, patients...

This page is intended to give you the information you need to recognise sickle cell disease and to help someone who has it to lead a good life. Contents Basic Facts What are haemoglobin SC disease (Hb SC) and Sickle Beta-Thalassaemia (Hb S-Thal)? What are the symptoms of sickle cell disease?...

Sickle cell disease (SCD) results from the substitution of a valine residue for glutamic acid at position 6 in the beta-subunit of hemoglobin (Ingram, 1956). With a few minor exceptions, people with only one gene for hemoglobin S (Hb S) are phenotypically normal (sickle trait). People who inherit two Hb...

Advances are being made in the management of sickle cell disease for all age groups. This review discusses the progress in amelioration of symptoms, problems unique to particular age groups, and the types of drugs and treatments currently under investigation (full text)

Multidisciplinary Management of Orthopedic Patients With Sickle Cell Disease Sickle cell disease, an autosomal-recessive disorder, produces abnormal hemoglobin and erythrocytes, which leads to hemolytic anemia and microvascular occlusion. Patients with sickle cell disease often present with orthopedic disease manifestations requiring surgical intervention, with the most common indications being osteonecrosis and osteomyelitis....

Bone Infarction Flow patterns in the marrow predispose it to infarction. The slowing of blood flow through the marrow space allows for regional hypoxia and thus sickling of red cells, leading to infarction. The proximal epiphysis of long bones, especially the humerus and femer is the most common location of infarction...

The Division of Blood Diseases and Resources (DBDR) of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), supports grants for the Comprehensive Sickle Cell Centers to focus on multi-disciplinary programs of basic, applied, and clinical research, and also to include relevant service activities in diagnosis,...

Osteomyelitis: - look for OM in multiple areas and in the diaphisis of long bones as compared to the metaphysis in unaffected children; - diagnosis of osteomyelitis: in patients with sickle cell anemia...

Rapid Search using as seed, "Relative rates and features of musculoskeletal complications in adult sicklers" 2004 Paper from Cameroun

Sickle cell disease is one of the more common abnormalities of haemoglobin. The single substitution of valine for glutamic acid alters the folding of the protein and its response to deoxygenation. The inheritance is autosomal dominent, but generally the disease is more severe in homozygous individuals. Other haemoglobinopathies may affect...

Introduction Sickle Cell Anemia (SCA) is caused by a change in the chemical composition of the protein (hemoglobin or Hgb) that carries the oxygen inside of the red blood cells (RBC's). Normal Hgb is a round or ball-shaped folded molecule composed of 4 protein subunits - 2 alpha chains...

Background: Sickle cell disease (SCD) and its variants are genetic disorders of mutant hemoglobins (Hb). The most common form found in North America is homozygous Hb S disease, first described by Herrick in 1910. Morbidity, frequency of crisis, degree of anemia, and the organ systems involved vary considerably from individual...